Publications

2022

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Nicholas Ball, Remi Bars, Philip A. Botham, Andreea Cuciureanu, Mark T. D. Cronin, John E. Doe, Tatsiana Dudzina, Timothy W. Gant, Marcel Leist & Bennard van Ravenzwaay

2021

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Xenia Dolde, Christiaan Karreman, Marianne Wiechers, Stefan Schildknecht and Marcel Leist

2021

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Dominik Loser, Karin Grillberger, Maria G. Hinojosa, Jonathan Blum, Yves Haufe, Timm Danker, Ylva Johansson, Clemens Möller, Annette Nicke, Susanne H. Bennekou, Iain Gardner, Caroline Bauch, Paul Walker, Anna Forsby, Gerhard F. Ecker, Udo Kraushaar & Marcel Leist

2021

Cellular Electrophysiological Recording: Mirroring Action Potentials: Label Free, Accurate, and Noninvasive Electrophysiological Recordings of Human-Derived Cardiomyocytes

Andrea Barbaglia, Michele Dipalo, Giovanni Melle, Giuseppina Iachetta, Lieselot Deleye, Aliaksandr Hubarevich, Andrea Toma, Francesco Tantussi, Francesco De Angelis

2021

Probing ND7/23 neuronal cells before and after differentiation with SERS using Sharp-tipped Au nanopyramid arrays

Marzia Iarossi, Aliaksandr Hubarevich, Giuseppina Iachetta, Michele Dipalo, Jian-An Huang, Daniel Darvill, Francesco De Angelis

2021

Passive recording of bioelectrical signals from non-excitable cells by fluorescent mirroring

Rosalia Moreddu, Alessio Boschi, Marta d’Amora, Aliaksandr Hubarevich, Michele Dipalo,* Francesco De Angelis*

2022

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Florian Seidel; Anna Cherianidou; Franziska Kappenberg; Miriam Marta; Nadine Dreser; Jonathan Blum; Tanja Waldmann; Nils Blüthgen; Johannes Meisig; Katrin Madjar; Margit Henry;

2022

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Christian Scheibe; Christiaan Karreman; Stefan Schildknecht; Marcel Leist; Karin Hauser

2023

Assay for evaluation of proarrhythmic effects of herbal products: Case study with 12 Evodia preparations

Bozhidar Baltov; Stanislav Beyl; Igor Baburin; Jakob Reinhardt; Phillip Szkokan; Aleksandra Garifulina; Eugen Timin; Udo Kraushaar; Olivier Potterat; Matthias Hamburger; Philipp Kügler;

2023

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Anna-Sophie Spreng; Markus Brüll; Heidrun Leisner; Ilinca Suciu; Marcel Leist

2022

Optimization of the TeraTox assay for preclinical teratogenicity assessment

Manuela Jaklin; Jitao David Zhang; Nicole Schaefer; Nicole Clemann; Paul Barrow; Erich Kueng; Lisa Sach-Peltason; Claudia McGinnis; Marcel Leist; Stefan Kustermann

2022

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Anna-Katharina Holzer; Christiaan Karreman; Ilinca Suciu; Lara-Seline Furmanowsky; Harald Wohlfarth; Dominik Loser; Wilhelm G Dirks; Emilio Pardo González; Marcel Leist

2022

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Anna Cherianidou; Florian Seidel; Franziska Kappenberg; Nadine Dreser; Jonathan Blum; Tanja Waldmann; Nils Blüthgen; Johannes Meisig; Katrin Madjar; Margit Henry; Tamara Rotshteyn;

2022

G × E interactions as a basis for toxicological uncertainty

Ilinca Suciu, David Pamies, Roberta Peruzzo, Petra H. Wirtz, Lena Smirnova, Giorgia Pallocca, Christof Hauck, Mark T. D. Cronin, Jan G. Hengstler, Thomas Brunner, Thomas Hartung, Ivano Amelio & Marcel Leist

2023

Long-term in vitro recording of cardiac action potentials on microelectrode arrays for chronic cardiotoxicity assessment

Giuseppina Iachetta, Giovanni Melle, Nicolò Colistra, Francesco Tantussi, Francesco De Angelis & Michele Dipalo

2023

Direct recording of action potentials of cardiomyocytes through solution processed planar electrolyte-gated field-effect transistors

Adrica Kyndiah, Michele Dipalo, Alireza Molazemhosseini, Fabrizio Antonio Viola, Francesco Modena, Giuseppina Iachetta, Nicolas F. Zorn, Felix J. Berger, Jana Zaumseil, Mario Caironi, Francesco De Angelis

2022

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Udo Kraushaar; Karin Gebhardt; Timm Danker; Jasmin Schaefer

2023

Establishment of a Human Cell-Based in Vitro Battery to Assess Developmental Neurotoxicity Hazard of Chemicals

Jonathan Blum; Stefan Masjosthusmann; Kristina Bartmann; Farina Bendt; Xenia Dolde; Arif Dönmez; Nils Förster; Anna-Katharina Holzer; Ulrike Hübenthal; Hagen Eike Keßel; Sadiye Kilic; Jördis Klose; Melanie Pahl; Lynn-Christin Stürzl; Iris Mangas; Andrea Terron; Kevin M. Crofton; Martin Scholze; Axel Mosig; Marcel Leist; Ellen Fritsche

2022

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Anna-Katharina Holzer; Ilinca Suciu; Christiaan Karreman; Thomas Goj; Marcel Leist

2023

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Ilinca Suciu; Johannes Delp; Simon Gutbier; Anna-Katharina Ückert; Anna-Sophie Spreng; Philipp Eberhard; Christiaan Karreman; Falk Schreiber; Katrin Madjar; Jörg Rahnenführer; Ivana Celardo; Ivano Amelio; Marcel Leist

2023

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

Philip Botham; Mark T. D. Cronin; Richard Currie; John Doe; Dorothee Funk-Weyer; Timothy W. Gant; Marcel Leist; Sue Marty; Bennard van Ravenzwaay; Carl Westmoreland

2022

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Pallocca, Giorgia; Rovida, Costanza; Leist, Marcel

2022

On the usefulness of animals as a model system (part II): Considering benefits within distinct use domains

Pallocca, Giorgia; Leist, Marcel